Meaning of non sedating

Before the era of modern medicine, the most commonly prescribed sedative to ease tension, cause relaxation and help forget problems was alcohol.Its beneficial effects were definitely the reason why alcohol gained such popularity and is still the most commonly abused sedative of all time.This is best explained if we observe two commonly prescribed groups of drugs – barbiturates and benzodiazepines.For example, barbiturate-type drugs cause general depression of most neuronal activity, thus they are considered nonselective.1974) and the RASS (Richmond Agitation-Sedation Scale).The American Society of Anesthesiologists defines the continuum of sedation as follows: Prior to any oral sedation methods being used on a patient, screening must be done to identify possible health concerns.Sedatives are a diverse group of drugs manufactured for medical purposes to relax the central nervous system.Also known as tranquillizers or central nervous system (CNS) depressants, they encompass drug classes such as barbiturates, benzodiazepines, non-benzodiazepine sedative-hypnotics, anesthetics, antihistamines and opioid narcotics, as well as herbal compounds.

Sedatives are usually classified according to the way they affect the human body.That is the reason why their use is practically always accompanied by certain degree of cognitive function impairment.In contrast, benzodiazepines selectively affect the neurons that have receptors for the neurotransmitter gamma-aminobutyric acid (GABA), which is a crucial inhibitory transmitter in several regions of the brain.Because of their toxicity, bromides were replaced by barbiturates in the early 20th century, which were initially also heralded as effective and safe sedative drugs.However, in a short period of time problems with dependence, tolerance and lethal overdosing became evident.

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Before using sedation, doctors try to identify any of the following that may apply: known drug allergies and sensitivities, hypertension, heart defects, kidney disease, other allergens, such as latex allergy, history of stroke or transient ischemic attack (TIA) (certain oral sedation methods may trigger a TIA), neuromuscular disorders (such as muscular dystrophy), or a current list of medications and herbal supplements taken by the patient.

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