Is lexapro activating or sedating
The usual dosage of the drug is 20 mg orally once daily throughout the month10 .
Administration of fluoxetine during the late luteal phase alone has been investigated in a small study11 of 24 women with PMDD and no psychiatric history.
This article is an update of information about the newer agents for depression and new indications for older antidepressants.
Selective serotonin reuptake inhibitors (SSRIs) have replaced tricyclic antidepressants as the drugs of choice in the treatment of depressive disorders, mainly because of their improved tolerability and safety if taken in overdose.
Improvement in symptoms of tension, irritability, and dysphoria has been demonstrated.9 [Evidence level A, randomized controlled trial (RCT)] Side effects were comparable with those reported in studies of fluoxetine used for other indications.SSRIs block the reuptake of serotonin (5-HT) into the presynaptic nerve terminal, thereby enhancing serotonin neurotransmission, which presumably results in their antidepressant effects.Although this is the predominant mechanism of action of this class of drugs, each SSRI has a slightly different pharmacologic profile that leads to its distinct clinical activity, side effects, and drug interactions.3 Six SSRIs are currently marketed in the United States; five of them have been approved by the U. Food and Drug Administration (FDA) for the treatment of depression Costs are average wholesale prices for 30 days of the lowest-dose therapy from Red Book. J.: Medical Economics Data, 2002, rounded to the nearest dollar.The choice of antidepressant drug depends on the agent's pharmacologic profile, secondary actions, and tolerability.Sexual dysfunction related to the use of antidepressants may be addressed by reducing the dosage, switching to another agent, or adding another drug to overcome the sexual side effects.
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The drug was taken for 14 days premenstrually for only three menstrual cycles. Stamford, Conn.: Appleton & Lange, 1999;1154–5Fluoxetine may be an appropriate antidepressant choice in patients with hypersomnia or psychomotor retardation and should probably be avoided in patients with concomitant anxiety, panic, and agitation.3Sertraline (Zoloft) is begun at a dosage of 50 mg per day and titrated to a dosage range of 100 to 200 mg per day in a single daily dose or divided daily doses12 .