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[Date last reviewed: 2019-03-14] Sex determination switch protein which controls sexual development by sex-specific splicing.

Regulates dosage compensation in females by suppressing hyperactivation of X-linked genes.

It is important to be aware that phenotypic parameters of mutant alleles and allele combinations can be very sensitive to culture conditions and genetic background.

A number of positive regulators of Sxl are known, including the genes da, fs(1)A1621, sis-a, and sis-b.

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